Antipsychotic Polypharmacy and Corrected QT Interval: A Systematic Review
نویسندگان
چکیده
منابع مشابه
Antipsychotic Dose Mediates the Association between Polypharmacy and Corrected QT Interval
Antipsychotic (AP) drugs have the potential to cause prolongation of the QT interval corrected for heart rate (QTc). As this risk is dose-dependent, it may be associated with the number of AP drugs concurrently prescribed, which is known to be associated with increased cumulative equivalent AP dosage. This study analysed whether AP dose mediates the relationship between polypharmacy and QTc int...
متن کامل[Corrected QT interval and corrected QT interval dispersion is worthwhile when interpreted with other repolarization measurements].
We read the article entitled ‘‘The effect of esmolol on corrected-QT interval, corrected-QT interval dispersion changes seen during anesthesia induction in hypertensive patients taking an angiotensin-converting enzyme inhibitor’’ by Ceker et al. with interest.1 The authors investigated the effects of esmolol on the hemodynamic, correctedQT (QTc) interval and corrected-QT interval dispersion (QT...
متن کاملChanges in the corrected QT interval and corrected QT dispersion during haemodialysis.
The link between increased QT dispersion and cardiac death in subjects with diabetes and arterial disease is well recognised. Corrected QT dispersion was studied in subjects with end stage renal failure on haemodialysis. Thirty one stable, chronic subjects on haemodialysis had 12-lead electrocardiograms (ECGs) taken before and after a single haemodialysis session. The QT interval was measured m...
متن کاملAntipsychotic Polypharmacy – time to review practice
The largest UK audit of APP was conducted by the Prescribing Observatory for Mental Health (POMHUK). A baseline audit of 3492 patients on 218 wards found that 43% were prescribed APP, and over onethird prescribed a high-dose of antipsychotic medication. A recent audit of APP at Graylands hospital, using a similar methodology to POMH-UK, found that 89.8% of patients were prescribed more than one...
متن کاملPlasma homocysteine levels associated with a corrected QT interval
BACKGROUND Little is known about the relationship between homocysteine (Hcy) levels and the QT interval. We examined the association of different Hcy levels with corrected QT (QTc) intervals in a general population. METHODS Plasma levels of Hcy were assessed in a population-based study of 7002 participants 35 years of age and older from 2012 to 2013. Twelve-lead ECGs were performed on all par...
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ژورنال
عنوان ژورنال: The Canadian Journal of Psychiatry
سال: 2015
ISSN: 0706-7437,1497-0015
DOI: 10.1177/070674371506000503